Systemic absorption of topically applied chloramphenicol eyedrops
- PMID: 508680
- PMCID: PMC1043594
- DOI: 10.1136/bjo.63.10.690
Systemic absorption of topically applied chloramphenicol eyedrops
Abstract
Five children under the age of 9 years had topical chloramphenicol drops administered 2-hourly to each eye for 5 to 7 days. Systemic absorption was not detected by 2 sensitive assays for the drug. The hazards of topical chloramphenicol and reports in the current literature are discussed.
Similar articles
-
Chloramphenicol in aqueous humor after topical application.Arch Ophthalmol. 1975 Mar;93(3):184-5. doi: 10.1001/archopht.1975.01010020192004. Arch Ophthalmol. 1975. PMID: 1094994 Clinical Trial.
-
[Chloramphenicol eyedrops in acute bacterial conjunctivitis. A comparison of 2 dosage regimes in general practice].Tidsskr Nor Laegeforen. 1994 Feb 28;114(6):671-3. Tidsskr Nor Laegeforen. 1994. PMID: 8191447 Clinical Trial. Norwegian.
-
Lack of evidence for systemic toxicity following topical chloramphenicol use.Eye (Lond). 1998;12 ( Pt 5):875-9. doi: 10.1038/eye.1998.221. Eye (Lond). 1998. PMID: 10070527 Review.
-
Systemic absorption of topical and subconjunctival gentamicin.Br J Ophthalmol. 1979 Oct;63(10):692-3. doi: 10.1136/bjo.63.10.692. Br J Ophthalmol. 1979. PMID: 508681 Free PMC article.
-
Minimizing systemic absorption of topically administered ophthalmic drugs.Surv Ophthalmol. 1993 May-Jun;37(6):435-56. doi: 10.1016/0039-6257(93)90141-s. Surv Ophthalmol. 1993. PMID: 8100087 Review.
Cited by
-
Comparative review of topical ophthalmic antibacterial preparations.Drugs. 2001;61(2):175-85. doi: 10.2165/00003495-200161020-00003. Drugs. 2001. PMID: 11270936 Review.
-
Ocular chloramphenicol and aplastic anaemia. Is there a link?Drug Saf. 1996 May;14(5):273-6. doi: 10.2165/00002018-199614050-00001. Drug Saf. 1996. PMID: 8800624 Review.
-
Treatment of ocular infections with topical antibacterials.Clin Pharmacokinet. 1999 Nov;37(5):351-60. doi: 10.2165/00003088-199937050-00001. Clin Pharmacokinet. 1999. PMID: 10589371 Review.
-
Widespread ocular use of topical chloramphenicol: is there justifiable concern regarding idiosyncratic aplastic anaemia?Br J Ophthalmol. 1996 Feb;80(2):182-4. doi: 10.1136/bjo.80.2.182. Br J Ophthalmol. 1996. PMID: 8814753 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources