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Comparative Study
. 1975 Aug;36(2):466-70.
doi: 10.1002/1097-0142(197508)36:2<466::aid-cncr2820360224>3.0.co;2-u.

Comparison of alpha1 fetoprotein radioimmunoassay method and liver scanning for detecting primary hepatic cell carcinoma

N Tonami, T Aburano, K Hisada
Comparative Study

Comparison of alpha1 fetoprotein radioimmunoassay method and liver scanning for detecting primary hepatic cell carcinoma

N Tonami et al. Cancer. 1975 Aug.

Abstract

Alpha1 (alpha 1) fetoprotein (AFP) radioimmunoassay method was routinely used in addition to liver scintigraphy to detect a primary hepatic cell carcinoma, and the diagnostic accuracy of both methods was compared. Twenty-one of 27 cases (78%) with primary hepatic cell carcinoma showed a positive AFP titer of over 200 ng/ml. In 3 of these AFP-positive cases, no focal defects could be found in liver scintigraphy, although subsequently performed celiac angiography revealed hypervascular shadows. On the contrary, 22 of 27 cases (81%) represented well-defined focal defects on scintigraphy. In 4 of these cases with a positive scan, the result of AFP was found to be negative. The overall diagnostic accuracy for detecting primary hepatic cell carcinoma with a combination of both methods was 93%.

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