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Clinical Trial
. 1971 Jun 26;2(5764):739-41.
doi: 10.1136/bmj.2.5764.739.

Potassium-sparing agents during diuretic therapy in hypertension

T J McKenna, J F Donohoe, T G Brien, J J Healy, B S Canning, F P Muldowney
Clinical Trial

Potassium-sparing agents during diuretic therapy in hypertension

T J McKenna et al. Br Med J. .

Abstract

Three pharmacological agents in use as "potassium-sparing" drugs have been tested by serial measurements of total exchangeable potassium (K(E)) during 4 to 12 weeks of oral diuretic therapy in hypertensive subjects. Triamterene seemed ineffective in the dosage used (50 mg twice daily). Spironolactone (25 mg twice daily) reduced K loss to a considerable extent, while Slow-K (32 mEq daily) completely reversed previous K(E) deficits. Plasma K levels were a poor indication of degree of K(E) restoration.

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