Relative contribution from different nerves to recurrent depression of Ia IPSPs in motoneurones

Abstract

1. The pattern of depression of Ia IPSPs by volleys in recurrent motor axon collaterals was investigated in motoneurones supplying hind-limb muscles in the cat. The test IPSPs were evoked by stimulation of dorsal roots and the conditioning antidromic volleys by stimulation of motor fibres in different peripheral muscle nerves.2. In all motor nuclei investigated the strongest depression of Ia IPSPs is evoked from motor fibres to muscles whose Ia afferents produce the IPSPs. For example, the Ia IPSP from the knee extensor recorded in motoneurones to a knee flexor is most effectively depressed by antidromic stimulation of motor fibres to the knee extensor.3. The origin of recurrent inhibition of alpha-motoneurones and of Ia inhibitory interneurones with the same Ia input display a striking similarity. This suggests that the same population of Renshaw cells mediates effects to motoneurones and to Ia inhibitory interneurones.4. The functional significance of impulses in motor axon collaterals was discussed and it was suggested that they have an important role in the control of the excitatory as well as inhibitory Ia actions to motoneurones. The recurrent inhibition may limit the Ia effects to excitation of homonymous motoneurones, which would provide optimal conditions for control of individual muscles via the gamma-loop.