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. 1971 Sep;12(9):702-4.
doi: 10.1136/gut.12.9.702.

Effect of lactulose on cerebral metabolism in patients with chronic portosystemic encephalopathy

I M James, M Garassini

Effect of lactulose on cerebral metabolism in patients with chronic portosystemic encephalopathy

I M James et al. Gut. 1971 Sep.

Abstract

Cerebral blood flow and cerebral metabolism were studied in six patients with moderately severe portosystemic encephalopathy before and after a 10-day course of lactulose. As a result of therapy there was a mean increase in cerebral oxygen utilization but no changes in either mean glucose consumption or in mean cerebral blood flow. It appears therefore that the abnormalities in cerebral metabolism that have been previously described in patients with hepatic encephalopathy can be improved by the oral administration of lactulose.

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References

    1. Clin Sci. 1965 Aug;29(1):179-91 - PubMed
    1. Lancet. 1966 Apr 23;1(7443):890-2 - PubMed
    1. Gut. 1966 Oct;7(5):497-501 - PubMed
    1. Lancet. 1969 Jan 18;1(7586):153 - PubMed
    1. Lancet. 1969 Nov 22;2(7630):1106-8 - PubMed