Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Sep;20(3):303-17.
doi: 10.1016/0010-7824(79)90102-1.

Pharmacokinetics of levonorgestrel in Indian women belonging to low socio-economic group

K M Nair, B Sivakumar, K Prema, B S Rao

Pharmacokinetics of levonorgestrel in Indian women belonging to low socio-economic group

K M Nair et al. Contraception. 1979 Sep.

Abstract

PIP: This study attempted to evaluate the effect of nutritional factors on the disposition of levonorgestrel (LN), as administered in a combination oral pill. Plasma samples from 11 low socioeconomic women were measured by radioimmunoassay after oral doses of 2 types of combination oral formulations, Primovlar-30 (500 mcg of LN and 30 mcg of ethinyl estradiol) and WHO-LNB (150 mcg of LN and 50 mcg of ethinyl estradiol). The following data suggest that nutritional status as reflected by anthropometry can modify the disposition of LN in women. With both preparations, plasma levels of LN reached a peak from 1-2 hours after administration and ranged from 4.6-16.2 ng/ml with Primovlar-30 and 2.8-14.4 ng/ml with LNB. The amount of LN in circulation at 48 hours was found to be more than .5 ng/ml. A triphasic decline in plasma levels of the steroid was established. Pharmacokinetic parameters calculated by graphical and regression analyses showed that the elimination half-life of the LN had a positive correlation and the peak plasma concentration a negative correlation with the 2 anthropometric indexes: weight/height sq. times 100 and skin-fold at triceps.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

LinkOut - more resources