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. 1971 Jan 29;171(3969):389-90.
doi: 10.1126/science.171.3969.389.

Aggregations of 35-nanometer particles associated with neuronal cytopathic changes in natural scrapie

A Bignami, H B Parry

Aggregations of 35-nanometer particles associated with neuronal cytopathic changes in natural scrapie

A Bignami et al. Science. .

Abstract

Neuronal vacuolation and intravacuolar budding of vesicles and cytoplasmic processes appear to be the most characteristic cellular lesion in natural scrapie, a chronic degenerative disease of the central nervous system of sheep which is transmissible by injection. Membrane-bound accumulations of the 35-nm particles are fotnd in the cytoplasmic processes that project inside the vacuoles of the neuronal perikaryon. Such particles are present only in a small number of vacuolated neurons.

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