doi: 10.1126/science.172.3980.290.
Alcohol dependence and opiate dependence: lack of relationship in mice
- PMID: 5102945
- DOI: 10.1126/science.172.3980.290
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Alcohol dependence and opiate dependence: lack of relationship in mice
Science.
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Abstract
According to a recently proposed hypothesis, physical dependence upon alcohol is due to the formation of an endogenous opiate. We tested the hypothesis by determining whether or not ethanol-dependent mice would show typical opiate-dependent behavior (withdrawal jumping syndrome) when challenged with the opiate antagonist naloxone. Our results do not support the hypothesis.
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