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. 1971 Mar;11(3):295-301.
doi: 10.1016/S0006-3495(71)86215-X.

Deoxyribonucleic acid synthesis in ultraviolet-light-irradiated Chinese hamster cells

R E Meyn, R M Humphrey

Deoxyribonucleic acid synthesis in ultraviolet-light-irradiated Chinese hamster cells

R E Meyn et al. Biophys J. 1971 Mar.

Abstract

Two mammalian cell lines, Chinese hamster ovary (CHO) which can recover colony-forming ability between fractionated doses of ultraviolet light (UV), and Chinese hamster B-14FAF28 which cannot recover, were tested for the ability to bypass UV-induced photoproducts in DNA during postirradiation DNA synthesis. The molecular weight distributions of newly synthesized DNA in UV-irradiated populations of both cell lines showed evidence for photoproduct bypass. Hence, the bypass mechanism does not correlate with recovery after UV.

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