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. 1979 Oct 26;59(1-2):103-6.
doi: 10.1016/0014-2999(79)90029-3.

Anticholinergic behavioral effect of phencyclidine

S D Glick, R D Cox, S Maayani, R D Meibach

Anticholinergic behavioral effect of phencyclidine

S D Glick et al. Eur J Pharmacol. .

Abstract

Phencyclidine (PCP) impaired spatial alternation performance in rats. This effects was mimicked by antimuscarinic anticholinergics (scopolamine, atropine) and PCP derivatives (ketamine, cyclohexamine) but not by a variety of other agents. Muscarinic cholinergic agonists antagonized PCP. Impairment of spatial alteration performance by PCP appears to be mediated, at least in part, by and anticholinergic action; this is the first instance of a behavioral effect of PCP that can be largely attributed to a specific mechanism.

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