Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Sep;360(9):1211-6.
doi: 10.1515/bchm2.1979.360.2.1211.

Novel opioid peptides derived from casein (beta-casomorphins). I. Isolation from bovine casein peptone

V Brantl, H Teschemacher, A Henschen, F Lottspeich

Novel opioid peptides derived from casein (beta-casomorphins). I. Isolation from bovine casein peptone

V Brantl et al. Hoppe Seylers Z Physiol Chem. 1979 Sep.

Abstract

A material which displayed opioid activity in the guinea pig ileum longitudinal muscle-myenteric plexus preparation was extracted from an enzymatic casein digest into chloroform/methanol. The extract was roughly purified by adsorption/desorption procedures using charcoal and Amberlite XAD-2 resin as adsorbents. A high degree of purity was achieved by high-pressure liquid chromatography of the material on muBondapak C18 and mu-Porasil columns and finally by gel filtration chromatography on a Bio-Gel P-2 column. Several pronase-resistant compounds with opioid activity were obtained.

PubMed Disclaimer

LinkOut - more resources