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. 1971 Oct 22;174(4007):421-2.
doi: 10.1126/science.174.4007.421.

Disposition of morphine in man

S Spector, E S Vesell

Disposition of morphine in man

S Spector et al. Science. .

Abstract

The disposition of morphine was investigated by means of radioimmunoassay after a single intravenous dose (10 milligrams per 70 kilograms) was administered to 10 adult normal male subjects who had not received other drugs for 2 weeks preceding the study. A multiphasic decline in serum concentrations of morphine occurred. Detectable blood concentrations of morphine, or of a metabolite, or of both persisted for 48 hours after a single intravenous dose.

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