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. 1971 Apr;122(2):135-8.
doi: 10.1042/bj1220135.

Incorporation of label from D- -hydroxy( 14 C)butyrate and (3- 14 C)acetoacetate into amino acids in rat brain in vivo

J E Cremer

Incorporation of label from D- -hydroxy( 14 C)butyrate and (3- 14 C)acetoacetate into amino acids in rat brain in vivo

J E Cremer. Biochem J. 1971 Apr.

Abstract

The metabolism of ketone bodies by rat brain was studied in vivo. Rats starved for 48h were given either d-beta-hydroxy[3-(14)C]butyrate or [3-(14)C]acetoacetate by intravenous injection and killed after 3 or 10min. Total radioactivity in the acid-soluble material of the brain and the specific radioactivities of the brain amino acids glutamate, glutamine, aspartate and gamma-aminobutyrate were determined. A group of fed animals were also given d-beta-hydroxy[3-(14)C]butyrate. In the brains of all animals (14)C was present in the acid-soluble material and the specific radioactivity of glutamate was greater than that of glutamine.

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