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. 1971 Feb;121(3):447-52.
doi: 10.1042/bj1210447.

Formation of malate from glyoxylate in animal tissues

C C Liang, L C Ou

Formation of malate from glyoxylate in animal tissues

C C Liang et al. Biochem J. 1971 Feb.

Abstract

1. Incubation of rat liver homogenate with [1-(14)C]glyoxylate, ATP and acetate shows a rapid sequential incorporation of radioactivity into malate, oxaloacetate and citrate. 2. In liver from normal rats the rate of the formation of each substance in question is higher than that in liver from thiamin-deficient rats. 3. The net accumulation of malate is greater with liver from thiamin-deficient rats. Its further metabolism is retarded, it is suggested, by inhibitors formed by a condensation of glyoxylate and oxaloacetate.

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