Reproductive ability and progeny of F 1 lead-toxic rats
- PMID: 5123251
Reproductive ability and progeny of F 1 lead-toxic rats
Abstract
PIP: The relationship of chronic lead ingestion and reduced reproductive performance was investigated with regard to the relative paternal and maternal effect of lead as measured by the progeny of F-one lead toxic rats. Paternal lead-toxic effect on pups' development was manifested by a retardation of embroynic growth and a reduction in the number of weaned pups per litter. The maternal effects of lead toxicity were seen in reduced litter size, retardation of fetal development and impaired postnatal survival. When both maternal and paternal effects of lead toxicity coexisted, all previously identified components were manifested and resulted in the birth of a few, precariously small pups which had a 30% survival rate. The effects of lead upon reproduction in the rat can be classified as gametotoxic, intrauterine and extrauterine.
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