Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1971 Nov 12;174(4010):712-4.
doi: 10.1126/science.174.4010.712.

Creation of "amyloid" fibrils from Bence Jones proteins in vitro

G G Glenner, D Ein, E D Eanes, H A Bladen, W Terry, D L Page

Creation of "amyloid" fibrils from Bence Jones proteins in vitro

G G Glenner et al. Science. .

Abstract

"Amyloid" fibrils have been created from some human Bence Jones proteins by proteolytic digestion under physiologic conditions. These fibrils with an antiparallel, beta-pleated sheet conformation consist of only a portion of the variable region of the immunoglobulin light polypeptide chain and share the physical properties of amyloid fibrils. The relation between amyloidosis and immunoglobulins is thus more firmly established and a pathogenetic mechanism for amyloid fibril formation is suggested.

PubMed Disclaimer

LinkOut - more resources