Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979;46(2):175-80.
doi: 10.1007/BF01250337.

Clozapine induced increase of human plasma norepinephrine

M Sarafoff, L Davis, E Rüther

Clozapine induced increase of human plasma norepinephrine

M Sarafoff et al. J Neural Transm. 1979.

Abstract

Four psychotic patients and 5 controls were treated with clozapine (200--400 mg/day during 30 days, patients, respectively 100 mg/day during 7 days, controls) and plasma norepinephrine (NE) concentration was measured. In the morning, shortly after end of sleep, plasma NE concentration was significantly increased under clozapine treatment in both populations. The effects of clozapine were explained with a direct pharmacological action of the drug on NE receptors.

PubMed Disclaimer

References

    1. Biochem Pharmacol. 1965 Dec;14(12):1896-7 - PubMed
    1. Life Sci. 1975 Feb 1;16(3):375-84 - PubMed
    1. Psychopharmacologia. 1975;41(1):27-33 - PubMed
    1. Eur J Pharmacol. 1974 Jul;27(2):180-90 - PubMed
    1. Life Sci. 1976 Jun 1;18(11):1315-25 - PubMed