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. 1979 Oct;68(10):1239-43.
doi: 10.1002/jps.2600681011.

Microbial transformations and 13C-NMR analysis of colchicine

C D Hufford, C C Collins, A M Clark

Microbial transformations and 13C-NMR analysis of colchicine

C D Hufford et al. J Pharm Sci. 1979 Oct.

Abstract

Several microorganisms were screened for their ability to biotransform colchicine, and two were selected for preparative scale fermentations. Streptomyces spectabilis and Streptomyces griseus both produced O2-demethylcolchicine and O3-demethylcolchicine but in different amounts. The 13C-NMR assignments of colchicine, O10-demethylcolchicine, and trimethylcolchicinic acid are reported and were used to help identify the structures of the metabolites.

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