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. 1976 May 13;429(3):629-34.
doi: 10.1016/0005-2744(76)90312-0.

Identification of the chemical groups involved in the binding of periodate-oxidized NADP+ to 6-phosphogluconate dehydrogenase

F Dallocchio, R Negrini, M Signorini, M Rippa

Identification of the chemical groups involved in the binding of periodate-oxidized NADP+ to 6-phosphogluconate dehydrogenase

F Dallocchio et al. Biochim Biophys Acta. .

Abstract

Periodate-oxidized NADP+ binds specifically and reversibly to the NADP+ binding site of 6-phosphogluconate dehydrogenase (EC 1.1.1.44) from Candida utilis. The inhibition can be stabilized by reduction with sodium borohydride. It has been shown that an aldehydic group of the inhibitor forms a Schiff base with a lysine residue of the enzyme.

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