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. 1971 Dec;12(12):984-7.
doi: 10.1136/gut.12.12.984.

Changes of the smooth endoplasmic reticulum induced by rifampicin in human and guinea-pig hepatocytes

A M Jezequel, F Orlandi, L T Tenconi

Changes of the smooth endoplasmic reticulum induced by rifampicin in human and guinea-pig hepatocytes

A M Jezequel et al. Gut. 1971 Dec.

Abstract

Rifampicin induces a proliferation of the smooth endoplasmic reticulum in guinea-pig and human hepatocytes. This may support the hypothesis of enhancement of drug-metabolizing enzymes induced by the drug. However, the pattern of proliferation is not similar in man and in guinea-pig hepatocytes. Some caution is needed in the study of enzyme induction in man and in extrapolations from animal to human data.

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