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. 1971 Nov;43(3):677-80.
doi: 10.1111/j.1476-5381.1971.tb07199.x.

Pharmacokinetics of cyclophosphamide in man

J L Cohen, J Y Jao, W J Jusko

Pharmacokinetics of cyclophosphamide in man

J L Cohen et al. Br J Pharmacol. 1971 Nov.

Abstract

1. The pharmacokinetics of cyclophosphamide were investigated in cancer patients. The data can be characterized by a two-compartment open model. The half life of the elimination phase of the drug ranged between 3 and 11 hours.2. Extensive tubular reabsorption of the drug resulted in the excretion of only a small percentage of the administered dose. The mean renal clearance was 10.7 ml/minute.3. The calculated fraction of the dose of drug which was metabolized averaged 88%.

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References

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