Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1971 Nov;125(1):235-40.
doi: 10.1042/bj1250235.

Biosynthesis of the carbohydrate portions of immunoglobulin M

R M Parkhouse, F Melchers

Biosynthesis of the carbohydrate portions of immunoglobulin M

R M Parkhouse et al. Biochem J. 1971 Nov.

Abstract

Incorporations of radioactive mannose, galactose and fucose into MOPC 104E mouse plasma-cell tumour suspensions suggest a stepwise addition of carbohydrate residues to immunoglobulin M (IgM) during the process of secretion. Mannose and glucosamine residues are added at an early stage, whereas galactose and fucose are added just before, or at the time that, IgM leaves the cell. Free light chains secreted in excess by the same tumour cells incubated with mannose, galactose or fucose contained barely detectable amounts of radioactivity.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Proc Natl Acad Sci U S A. 1970 Aug;66(4):1183-9 - PubMed
    1. J Mol Biol. 1970 Jul 28;51(2):287-301 - PubMed
    1. Biochim Biophys Acta. 1963 Oct 29;78:342-50 - PubMed
    1. Biochem J. 1971 Jul;123(4):629-34 - PubMed
    1. Biochem J. 1971 Jul;123(4):635-41 - PubMed