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. 1971 Oct;124(4):695-700.
doi: 10.1042/bj1240695.

Synthesis and enzymic hydroxylation of protocollagen model peptide containing a hydroxyproline residue

Y Kikuchi, D Fujimoto, N Tamiya

Synthesis and enzymic hydroxylation of protocollagen model peptide containing a hydroxyproline residue

Y Kikuchi et al. Biochem J. 1971 Oct.

Abstract

1. Two protocollagen model peptides, Z-Gly-Pro-Hyp-Gly-(Pro-Pro-Gly)(5) (Z, benzyloxycarbonyl) and AOC-(Pro-Pro-Gly)(6) (AOC, tert.-pentyloxycarbonyl), were synthesized and hydroxylated with protocollagen proline hydroxylase. 2. The two model peptides were hydroxylated equally. The results suggest that the hydroxyl group of hydroxyproline contained in the N-terminal region of the peptide has no effect on the enzymic hydroxylation of the model peptide.

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