The metabolic spectrum of halofenate

Abstract

Halofenate is a new antilipemic drug which is an ester of carboxylic acid. In dosages ranging from 10 to 15 mg/kg, halofenate produces prominent decreases in serum triglycerides and uric acid, with only a slight reduction in serum cholesterol. The decrease in serum uric acid is due to augumented uricosuria. Halofenate is less antilipemic, but more antiuricemic than clofibrate. It apparently interferes with the protein binding of some hormones (thyroid) and drugs (tolbutamide), which can produce changes in the laboratory or clinical findings. In general, halofenate was well tolerated, except for occasional gastrointestinal symptoms.