The effect of thiols on immunologic release of slow reacting substance of anaphylaxis. I. Human lung
- PMID: 51872
Item in Clipboard
The effect of thiols on immunologic release of slow reacting substance of anaphylaxis. I. Human lung
J Immunol.
1975 Oct.
Abstract
Preincubation of human lung fragments with cysteine for 2.5 to 5.0 min resulted in dose-dependent, selective enhancement of the antigen-induced or anti-IgE-induced formation and release of slow reacting substance of anaphylaxis (SRS-A). Comparable effects were observed with sodium sulfide and thioglycolate but not with other more potent reducing agents or metabolites of cysteine. Sulfhydryl alkylated derivatives of cysteine were ineffective. The effects observed with the active thiols were easily reversed and could not be attributed to an action in the bioassay or on SRS-A itself. The physicochemical characteristics of the contractile activity were identical to those described for SRS-A.
Similar articles
-
The effect of thiols on the immunologic release of slow reacting substance of anaphylaxis. II. Other in vitro and in vivo models.J Immunol. 1976 Feb;116(2):392-7. J Immunol. 1976. PMID: 55439
-
Dissociation of the immunologic release of histamine and slow reacting substance of anaphylaxis from human lung using cytochalasins A and B-1.J Immunol. 1975 Jan;114(1 Pt 1):182-6. J Immunol. 1975. PMID: 46240
-
Pharmacologic inhibition of the antigen-induced release of histamine and slow reacting substance of anaphylaxis (SRS-A) from monkey lung tissues mediated by human IgE.J Immunol. 1971 May;106(5):1267-73. J Immunol. 1971. PMID: 4102404 No abstract available.
-
The formation and release of slow-reacting substance of anaphylaxis.Monogr Allergy. 1977;12:231-40. Monogr Allergy. 1977. PMID: 335216 Review. No abstract available.
-
Symposium on allergic lung disease. IV. Immunologic mechanisms for release of chemical mediators of anaphylaxis from human lung tissue.Can Med Assoc J. 1974 Feb 16;110(4):431 passim. Can Med Assoc J. 1974. PMID: 4134081 Free PMC article. Review.
Cited by
-
Metabolism of leukotrienes.Mol Cell Biochem. 1985 Nov;69(1):7-16. doi: 10.1007/BF00225922. Mol Cell Biochem. 1985. PMID: 3001504 Review.
-
Characterization of slow reacting substances (SRSs) of rat basophilic leukemia (RBL-1) cells: effect of cysteine on SRS profile.Proc Natl Acad Sci U S A. 1980 Nov;77(11):6481-5. doi: 10.1073/pnas.77.11.6481. Proc Natl Acad Sci U S A. 1980. PMID: 6109281 Free PMC article.
-
Comparison of rat, mouse, guinea-pig and human slow reacting substance of anaphylaxis (SRS-A).Experientia. 1979 Mar 15;35(3):361-3. doi: 10.1007/BF01964353. Experientia. 1979. PMID: 109304
-
Radioimmunoassay of the leukotrienes of slow reacting substance of anaphylaxis.Proc Natl Acad Sci U S A. 1981 Dec;78(12):7692-6. doi: 10.1073/pnas.78.12.7692. Proc Natl Acad Sci U S A. 1981. PMID: 6950409 Free PMC article.
-
Release of a slow-reacting substance from rabbit platelets.J Clin Invest. 1981 Dec;68(6):1586-91. doi: 10.1172/jci110413. J Clin Invest. 1981. PMID: 6119324 Free PMC article.