In vivo effect of human chorionic gonadotropin on the migration of inflammatory cells in intact or castrated male and female guinea-pigs. A quantitative histological study. I. Study of intact male and female guinea-pigs

Abstract

The migration of inflammatory cells and fibroblasts into dacron mesh tissue (Mersilene), immersed in a suspension of live BCG and implanted s.c. into intact male and female guinea-pigs treated with either commercial or purified human chorionic gonadotropin was investigated. Cell counts showed that in treated animals a significant reduction (about 70%) of whole cells occurred. The effect was maximal on neutrophil granulocytes (a reduction of 85%) by Day 5 after grafting. No significant differences appeared between males and females or between commercial and purified human chorionic gonadotropin.