The linkage arrangement of four rabbit beta-like globin genes
- PMID: 519768
- DOI: 10.1016/0092-8674(79)90238-1
The linkage arrangement of four rabbit beta-like globin genes
Abstract
Four different regions of rabbit beta-like globin gene sequences designated beta 1, beta 2, beta 3 and beta 4 were identified in a set of clones isolated from a bacteriophage lambda library of chromosomal DNA fragments (Maniatis et al., 1978). Restriction mapping and blot hybridization (Southern, 1975) studies indicate that a subset of these clones containing beta 1 and beta 2 hybridizes to an adult beta-globin cDNA clone (Maniatis et al., 1976) more efficiently than to a human gamma-globin cDNA clone (Wilson et al., 1978), while another subset containing beta 3 and beta 4 displays the converse hybridization specificity. beta 1 was identified as the adult beta-globin gene, while beta 2, beta 3 and beta 4 have not been identified with any known rabbit globin polypeptides. Cross-hybridization and transcriptional orientation experiments indicate that the set of beta-like gene clones contains overlapping restriction fragments encompassing 44 kb of rabbit chromosomal DNA. In addition, all four genes have the same transcriptional orientation and are arranged in the order 5'-beta 4-beta 3-beta 2-beta 1-3'.
Similar articles
-
Molecular cloning and characterization of the human beta-like globin gene cluster.Cell. 1980 Apr;19(4):959-72. doi: 10.1016/0092-8674(80)90087-2. Cell. 1980. PMID: 6155216
-
The chromosomal arrangement of human alpha-like globin genes: sequence homology and alpha-globin gene deletions.Cell. 1980 May;20(1):119-30. doi: 10.1016/0092-8674(80)90240-8. Cell. 1980. PMID: 6446404
-
Isolation and characterization of the complete chicken beta-globin gene region: frequent deletion of the adult beta-globin genes in lambda.Nucleic Acids Res. 1981 Aug 11;9(15):3731-46. doi: 10.1093/nar/9.15.3731. Nucleic Acids Res. 1981. PMID: 6269092 Free PMC article.
-
The molecular genetics of human monogenic diseases.Biotechnol Genet Eng Rev. 1985;3:275-309. doi: 10.1080/02648725.1985.10647816. Biotechnol Genet Eng Rev. 1985. PMID: 3004535 Review. No abstract available.
-
Gene inserts. Introns and exons, a condensed review.Cell Biol Int Rep. 1980 May;4(5):433-45. doi: 10.1016/0309-1651(80)90030-2. Cell Biol Int Rep. 1980. PMID: 6249501 Review. No abstract available.
Cited by
-
Tissue-specific DNA methylation in a cluster of rabbit beta-like globin genes.Proc Natl Acad Sci U S A. 1980 Nov;77(11):6634-8. doi: 10.1073/pnas.77.11.6634. Proc Natl Acad Sci U S A. 1980. PMID: 6935674 Free PMC article.
-
Histone genes are clustered but not tandemly repeated in the chicken genome.Proc Natl Acad Sci U S A. 1981 May;78(5):2856-60. doi: 10.1073/pnas.78.5.2856. Proc Natl Acad Sci U S A. 1981. PMID: 6265918 Free PMC article.
-
The primary structures of two leghemoglobin genes from soybean.Nucleic Acids Res. 1982 Jan 22;10(2):689-701. doi: 10.1093/nar/10.2.689. Nucleic Acids Res. 1982. PMID: 6278428 Free PMC article.
-
The use of synthetic oligonucleotides as hybridization probes. II. Hybridization of oligonucleotides of mixed sequence to rabbit beta-globin DNA.Nucleic Acids Res. 1981 Feb 25;9(4):879-94. doi: 10.1093/nar/9.4.879. Nucleic Acids Res. 1981. PMID: 7232206 Free PMC article.
-
Transcription unit of the rabbit beta 1 globin gene.Mol Cell Biol. 1985 Jan;5(1):147-60. doi: 10.1128/mcb.5.1.147-160.1985. Mol Cell Biol. 1985. PMID: 2580228 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
