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. 1979 Sep-Oct;42(5):475-7.
doi: 10.1021/np50005a006.

Plant anticancer agents X. Isolation of camptothecin and 9-methoxycamptothecin from Ervatamia heyneana

S P Gunasekera, M M Badawi, G A Cordell, N R Farnsworth, M Chitnis

Plant anticancer agents X. Isolation of camptothecin and 9-methoxycamptothecin from Ervatamia heyneana

S P Gunasekera et al. J Nat Prod. 1979 Sep-Oct.

Abstract

The anticancer activity of the roots of Ervatamia heyneana (Apocynaceae) was found to be due principally to the known alkaloid, camptothecin (1). The closely related, but less active, 9-methoxycamptothecin (2) was also obtained. This is the first reported isolation of these biogenetically interesting alkaloids from the indole alkaloid rich Apocynaceae.

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