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. 1975 Aug;6(2):80-92.
doi: 10.1111/j.1399-0039.1975.tb00619.x.

Expression and segregation of HL-A antigens in D98/AH-2 by lymphocyte and fibroblast hybrids

R H Kennett, B Hampshire, B Bengtsson, W F Bodmer

Expression and segregation of HL-A antigens in D98/AH-2 by lymphocyte and fibroblast hybrids

R H Kennett et al. Tissue Antigens. 1975 Aug.

Abstract

Somatic cell hybrids between D98/AH-2 and fibroblasts or peripheral blood lymphocytes were analysed for the expression of HL-A antigens. The hybrids express the antigens of the donor lymphocytes or fibroblasts as well as other HL-A specificities from D98/AH-2, a HeLa derivative on which no HL-A could be detected by direct cytotoxicity. Segregant hybrid clones could be used to determine HL-A haplotypes and define the linkage relationships between these haplotypes and the PGM3 alleles expressed in the hybrids. An analysis of the HL-A antigens on D98/AH-2 and other HeLa derivates was done using absorption and a modified cytotoxicity assay.

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