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Comparative Study
. 1975 Feb;5(1):9-14.
doi: 10.1007/BF02027151.

The effect of Trimepranol on thrombocyte function and histamin release in the rat

R Nosal, Z Menyhardtová
Comparative Study

The effect of Trimepranol on thrombocyte function and histamin release in the rat

R Nosal et al. Agents Actions. 1975 Feb.

Abstract

Trimepranol a beta adrenergic blocking drug released serotonin from rat isolated and plasma-rich thrombocytes in vitro. The release was time- and dose-dependent. With the same concentrations this drug inhibited the histamine release from isolated rat mast cells. Aggregation of isolated or plasma-rich thrombocytes induced by ADP was inhibited by Trimepranol. The inhibition was dose, time dependent and reversed by calcium ions.

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References

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