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. 1979 Dec 20;7(8):2457-67.
doi: 10.1093/nar/7.8.2457.

Nucleosome dissociation and transfer in concentrated salt solutions

P C Stacks, V N Schumaker
Free PMC article

Nucleosome dissociation and transfer in concentrated salt solutions

P C Stacks et al. Nucleic Acids Res. .
Free PMC article

Abstract

We have examined the dissociation of nucleosomes into histones and free, 4.5S DNA over a range of sodium chloride concentrations between 0.25 and 1 M. We have also studied this dissociation as a function of nucleosome concentration at two salt concentrations, 0.8 M and 0.9 M. In addition, we have measured the kinetics of transfer of histone cores from nucleosomes onto recipient bacteriophage T7 DNA in 0.6, 0.7 and 0.8 M NaCl solutions. Although the mechanism of nucleosome transfer is unknown the data presented here are consistent with either a reversible dissociation of the nucleosome or DNA strand displacement by another DNA.

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