Effects of prostaglandin E2 and F2 alpha on the absorption and portal transport of sugar and on the local intestinal circulation

Abstract

With the isolated jejunum loop technique investigations of prostaglandin E2 and F2 alpha were made on canine intestinal absorption and transport of glucose and on the circulation of the intestinal loop. These compounds decreased glucose absorption; intra-arterial prostaglandin administration decreased the portal transport of glucose, but intraluminal administration caused an increase. PGE2 enhanced the circulation of the intestinal loop; intra-arterial PGF2 alpha diminished this circulation, whereas on intraluminal PGF2 alpha had no significant effect.