Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Jul;21(1):109-14.

The influence of C3b inactivator (KAF) concentration on the ability of serum to support complement activation

P J Lachmann, L Halbwachs

The influence of C3b inactivator (KAF) concentration on the ability of serum to support complement activation

P J Lachmann et al. Clin Exp Immunol. 1975 Jul.

Abstract

Minor elevation of the concentration of the C3b inactivator (KAF) in whole serum (by 15-25%) markedly inhibits the capacity of the serum to support complement activation by inulin, aggregated IgG and by low concentrations of CVF. However, there was no effect when large concentrations of CVF were used nor was the spontaneous ageing of C3 slowed by increased KAF concentrations. These findings show that the activity of the C3b feedback cycle can be reduced by raising the KAF concentration above physiological levels. This finding may provide a mechanism for damping down complement activation locally in vivo. It seems that the spontaneous ageing of C3 in vitro does not involve a KAF-inhibitable step and therefore cannot be involved to explain the 'C3 tickover' in vitro.

PubMed Disclaimer

References

    1. Anal Biochem. 1965 Feb;10:358-61 - PubMed
    1. J Exp Med. 1972 Apr 1;135(4):1003-8 - PubMed
    1. Lancet. 1973 Mar 3;1(7801):465-7 - PubMed
    1. Immunochemistry. 1973 Oct;10(10):695-700 - PubMed
    1. J Immunol. 1968 Apr;100(4):691-8 - PubMed

LinkOut - more resources