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. 1969 Feb;62(2):581-8.
doi: 10.1073/pnas.62.2.581.

Stereochemical analysis of the specificity of pancreatic RNAse with polyformycin as substrate: differentiation of the transphosphorylation and hydrolysis reactions

D C Ward, W Fuller, E Reich

Stereochemical analysis of the specificity of pancreatic RNAse with polyformycin as substrate: differentiation of the transphosphorylation and hydrolysis reactions

D C Ward et al. Proc Natl Acad Sci U S A. 1969 Feb.

Abstract

A stereochemical analysis of the substrate and inhibitor specificities of bovine pancreatic ribonuclease A is presented. A scheme is proposed in which the binding specificity for this protein-nucleic acid interaction is rationalized in terms of a simple system of H-bonds. The functional groups that govern substrate binding for transphosphorylation and hydrolysis, respectively, are considered and differentiated, and predictions are offered concerning the interaction of presumptive substrates with RNase.

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References

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