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. 1969 Apr;62(4):1077-84.
doi: 10.1073/pnas.62.4.1077.

Complex mitochondrial DNA in leukemic and normal human myeloid cells

D A Clayton, J Vinograd

Complex mitochondrial DNA in leukemic and normal human myeloid cells

D A Clayton et al. Proc Natl Acad Sci U S A. 1969 Apr.

Abstract

Mitochondrial DNA's from the peripheral blood of 14 patients with granulocytic leukemia contained a circular dimer form. No such structure could be found in M DNA's from three patients with nonmalignant proliferations of granulocytes. The frequency of the circular dimer form is reduced upon treatment with antileukemic drugs. The above results suggest that a significant relation exists between the formation and presence of the circular dimer M DNA form and granulocytic leukemia in man.

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References

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