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. 1969 Apr;62(4):1129-36.
doi: 10.1073/pnas.62.4.1129.

Solubilization of particulate proteins and nonelectrolytes by chaotropic agents

Y Hatefi, W G Hanstein

Solubilization of particulate proteins and nonelectrolytes by chaotropic agents

Y Hatefi et al. Proc Natl Acad Sci U S A. 1969 Apr.

Abstract

Chaotropic ions (those ions which favor the transfer of apolar groups to water) provide a highly effective means for the resolution of membranes and multicomponent enzymes and for increasing the water solubility of particular proteins and nonelectrolytes. The action of chaotropic agents is related to their effect on the structure and lipophilicity of water.

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References

    1. Biochemistry. 1968 Nov;7(11):3879-82 - PubMed
    1. Biochim Biophys Acta. 1962 Oct 8;64:170-3 - PubMed
    1. Adv Gerontol Res. 1967;2:77-120 - PubMed
    1. J Biol Chem. 1967 Nov 10;242(21):4854-66 - PubMed
    1. J Biol Chem. 1962 Jan;237:230-5 - PubMed

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