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. 1969 Jul;63(3):740-7.
doi: 10.1073/pnas.63.3.740.

Transformation and chromosome changes induced by Epstein-Barr virus in normal human leukocyte cultures

P Gerper, J Whang-Peng, J H Monroe

Transformation and chromosome changes induced by Epstein-Barr virus in normal human leukocyte cultures

P Gerper et al. Proc Natl Acad Sci U S A. 1969 Jul.

Abstract

Three separate attempts to establish long-term leukocyte cultures from the peripheral blood of a healthy adult who had no evidence of previous infection with Epstein-Barr virus were consistently unsuccessful. On the other hand, in vitro infection of buffy-coat cells of this donor with Epstein-Barr virus resulted in blastoid transformation of the lymphocytes and long-term growth potential. The transformation was accompanied by major chromosome changes. The significance of these findings in relation to lymphoproliferative diseases in man remains to be determined.

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