Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1969 Jul;63(3):820-7.
doi: 10.1073/pnas.63.3.820.

Two deoxyribonuclease activities within purified vaccinia virus

B G Pogo, S Dales

Two deoxyribonuclease activities within purified vaccinia virus

B G Pogo et al. Proc Natl Acad Sci U S A. 1969 Jul.

Abstract

Two DNases, both hydrolizing single-stranded DNA, were identified within highly purified particles of vaccinia virus. One of these, active optimally at pH 5.0, is an exonuclease and the other, most active at pH 7.8, is an endonuclease. These two activities were localized more specifically within the virus cores. Upon elimination of the envelopes, followed by removal of the lateral bodies of vaccinia, both DNases were activated, suggesting that a specific inhibitor of these enzymes may be present in the lateral bodies.

PubMed Disclaimer

References

    1. Virology. 1965 Sep;27(1):80-93 - PubMed
    1. Proc Natl Acad Sci U S A. 1966 Jun;55(6):1581-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1967 Jul;58(1):134-41 - PubMed
    1. Proc Natl Acad Sci U S A. 1968 Feb;59(2):598-605 - PubMed
    1. Proc Natl Acad Sci U S A. 1968 May;60(1):329-36 - PubMed

MeSH terms

Substances

LinkOut - more resources