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. 1969 Aug;63(4):1117-9.
doi: 10.1073/pnas.63.4.1117.

Increase in rat brain tyrosine hydroxylase activity produced by electroconvulsive shock

J M Musacchio, L Julou, S S Kety, J Glowinski

Increase in rat brain tyrosine hydroxylase activity produced by electroconvulsive shock

J M Musacchio et al. Proc Natl Acad Sci U S A. 1969 Aug.

Abstract

A sustained increase in the turnover of norepinephrine coupled with an increased concentration of that amine has, in a previous study, been observed in the brains of rats exposed to electroconvulsive shock twice daily for one week. The phenomenon has been further examined by studying the effects of a similar regimen of electroconvulsive shock upon tyrosine hydroxylase in the brain, since that enzyme appears to be rate-limiting in norepinephrine synthesis. A small (15%) but significant increase in the whole brain enzyme activity was found in the electroshock-treated animals. A significant increase of tyrosine hydroxylase activity was found in the brainstem (24%) and cortex (20%) of such animals.

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References

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