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. 1969 Sep;64(1):168-70.
doi: 10.1073/pnas.64.1.168.

Organic anion-binding protein in rat liver: drug induction and its physiologic consequence

H Reyes, A J Levi, Z Gatmaitan, I M Arias

Organic anion-binding protein in rat liver: drug induction and its physiologic consequence

H Reyes et al. Proc Natl Acad Sci U S A. 1969 Sep.

Abstract

The administration of phenobarbital to rats enhanced hepatic uptake of an organic anion, bromsulphalein, in vivo and simultaneously increased the amount of Y, a hepatic cytoplasmic organic anion-binding protein. This study supports the postulate that Y is a major determinant in the selective hepatic uptake of certain organic anions from plasma. Induction of Y may contribute to the enhanced hepatic uptake and metabolism of various organic anions (drugs, hormones, etc.) produced by phenobarbital and other agents.

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References

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