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. 1969 Sep;64(1):263-6.
doi: 10.1073/pnas.64.1.263.

Deuterated oxytocins: the synthesis and biological properties of a crystalline analog of deamino-oxytocin deuterated in the 5-asparagine position

A T Blomquist, D H Rich, B A Carlson, G A Allen, V J Hruby, H Takashima, L L Nangeroni, P Glose, V Du Vigneaud

Deuterated oxytocins: the synthesis and biological properties of a crystalline analog of deamino-oxytocin deuterated in the 5-asparagine position

A T Blomquist et al. Proc Natl Acad Sci U S A. 1969 Sep.

Abstract

This paper describes the synthesis and biological activity of [5-L-asparagine-alpha,beta,beta-d(3)]-deamino-oxytocin. The model peptide S-benzyl-beta-mercaptopropionyl-L- asparaginyl-alpha,beta,beta-d(3)-glycinamide was also prepared to observe the effect of the conditions of peptide synthesis on the deuterium content. It was found that normal synthetic procedures could be used without a significant loss in the deuterium content.The [5-L-asparagine-alpha,beta,beta-d(3)]-deamino-oxytocin had, within experimental error, the same avian vasodepressor and oxytocic activities as deamino-oxytocin itself.

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References

    1. J Org Chem. 1966 Dec;31(12):4121-7 - PubMed
    1. Nature. 1959 Jun 13;183(4676):1657-9 - PubMed
    1. Endocrinology. 1960 Mar;6:451-7 - PubMed
    1. Nature. 1964 Jan 4;201:76-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1968 Oct;61(2):688-92 - PubMed

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