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. 1969 Sep;64(1):290-5.
doi: 10.1073/pnas.64.1.290.

Release of trapped marker from liposomes by the action of purified complement components

J A Haxby, O Götze, H J Müller-Eberhard, S C Kinsky

Release of trapped marker from liposomes by the action of purified complement components

J A Haxby et al. Proc Natl Acad Sci U S A. 1969 Sep.

Abstract

Liposomes containing trapped glucose marker were prepared from the chloroform-soluble fraction of sheep erythrocyte membranes. These liposomes release glucose when incubated with rabbit anti-sheep erythrocyte serum and a source of complement. Experiments with purified human complement components show that loss of marker is absolutely dependent on the presence of components 2 and 8. An absolute requirement for component 9 cannot be demonstrated, although it stimulates glucose release from the liposomes. These results establish a parallelism between the response of biological membranes and liposomal membranes to antibody and complement.

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References

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