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. 1969 Sep;64(1):304-10.
doi: 10.1073/pnas.64.1.304.

On the geometrical arrangement of the protein subunits of human serum low-density lipoprotein: evidence for a dodecahedral model

H Pollard, A M Scanu, E W Taylor

On the geometrical arrangement of the protein subunits of human serum low-density lipoprotein: evidence for a dodecahedral model

H Pollard et al. Proc Natl Acad Sci U S A. 1969 Sep.

Abstract

Ultracentrifugal and electron microscopic studies of human serum low-density lipoprotein (LDL) and several of its derivatives led to the formulation of a model in which the 20 protein subunits, probably globular, are arranged in a dodecahedral pattern with icosahedral symmetry. In such a model the LDL surface is occupied by both protein and lipids, predominantly phospholipids, as supported by the results of the hydrolysis of LDL by phospholipase A and C. Neutral lipids (cholesterol esters and glycerides) would be in the interior of the molecule.

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References

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