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. 1969 Nov;64(3):1004-10.
doi: 10.1073/pnas.64.3.1004.

Neuronal tumor cells with excitable membranes grown in vitro

P Nelson, W Ruffner, M Nirenberg

Neuronal tumor cells with excitable membranes grown in vitro

P Nelson et al. Proc Natl Acad Sci U S A. 1969 Nov.

Abstract

Mouse neuroblastoma cells grown in vitro are capable of generating action potentials in response to electrical stimulation. A wide spectrum of responses was observed with different cells ranging from passive responses to action potentials. A hypothesis is proposed concerning the acquisition of electrical excitability as neuroblasts mature into neurons.

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References

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