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. 1969 Nov;64(3):863-9.
doi: 10.1073/pnas.64.3.863.

Evidence for a single-stranded adenovirus-associated virus genome: formation of a DNA density hybrid on release of viral DNA

J A Rose, K I Berns, M D Hoggan, F J Koczot

Evidence for a single-stranded adenovirus-associated virus genome: formation of a DNA density hybrid on release of viral DNA

J A Rose et al. Proc Natl Acad Sci U S A. 1969 Nov.

Abstract

Extracted adenovirus-associated virus DNA is known to be double-stranded, and, therefore, it has been assumed that these virus particles contain a double-stranded genome. Recent findings, however, have suggested that the DNA in virus particles is equivalent to only half the molecular weight of extracted molecules. A density analysis of DNA extracted from a mixture of virus particles containing either bromodeoxyuridine-substituted or unsubstituted DNA shows that virions contain single-stranded DNA which, when released, forms duplex structures. A similar circumstance is as yet unknown among other viruses.

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