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. 1979 Nov;31(7):207-9.

Proliferative effect of lithocholic acid on rat liver cell in culture

J F Jeannin, M Chessebeuf, M S Martin, A Lagneau, F Martin
  • PMID: 526544

Proliferative effect of lithocholic acid on rat liver cell in culture

J F Jeannin et al. Biomedicine. 1979 Nov.

Abstract

In contrast to cholic acid, deoxycholic acid and chenodeoxycholic acid, lithocholic acid (LCA) enhances the growth of rat liver cells in culture. Enhanced proliferation of LCA-treated rat liver cells persists even 12 days after LCA was removed. These findings could suggest a mutagenic effect of LCA, or a metabolite, on rat liver cells.

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