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. 1975 Sep;8(3):263-6.
doi: 10.1016/0022-1759(75)90120-9.

Peritoneal macrophages as target cells for measuring virus-specific T cell mediated cytotoxicity in vitro

R M Zinkernagel, P C Doherty

Peritoneal macrophages as target cells for measuring virus-specific T cell mediated cytotoxicity in vitro

R M Zinkernagel et al. J Immunol Methods. 1975 Sep.

Abstract

In inbred or outbred mice lysis of virally modified cells by thymus-derived lymphocytes occurs only within a H-2 compatible system. Peritoneal macrophages provide a convenient source of syngeneic target cells. They are readily infected in vitro with LCM virus, and show high levels of specific 51Cr release when exposed to T cells from LCM immune mice.

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