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Case Reports
. 1979 Dec 8;2(6203):1474-6.
doi: 10.1136/bmj.2.6203.1474.

Resetting of osmoreceptor response as cause of hyponatraemia in acute idiopathic polyneuritis

M D Penney, D Murphy, G Walters
Case Reports

Resetting of osmoreceptor response as cause of hyponatraemia in acute idiopathic polyneuritis

M D Penney et al. Br Med J. .

Abstract

In a patient with hyponatraemia associated with acute idiopathic polyneuritis plasma concentrations of antidiuretic hormone increased when hypertonic saline was infused intravenously, and urine osmolality rose concomitantly. A water load was excreted normally, while the plasma remained extremely hypo-osmolal. It is concluded that osmoregulation was functioning normally but was set abnormally low, possibly owing to a disturbance of the peripheral volume receptors.

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