Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Oct;251(2):271-9.
doi: 10.1113/jphysiol.1975.sp011091.

Effect of ascorbic acid on histamine metabolism in scorbutic guinea-pigs

I B Chatterjee, S D Gupta, A K Majumder, B K Nandi, N Subramanian

Effect of ascorbic acid on histamine metabolism in scorbutic guinea-pigs

I B Chatterjee et al. J Physiol. 1975 Oct.

Abstract

1. In guinea-pigs fed an ascorbic-acid-free diet, as the ascorbic acid levels decreased the histamine levels in blood and urine rose steadily to maxima in about 10-12 days. The elevated histamine levels persisted in the blood and urine of scorbutic guinea-pigs and the histamine levels in lung, gastric mucosa and spleen also increased. The increased histamine content of the urine, blood and other tissues in the ascorbic-acid-depleted condition could be brought back to normal levels by administration of a single dose of ascorbic acid 5 mg/100 g body wt. guinea-pig. 3. The drop in the elevated histamine level was not due to an indirect effect of ascorbic acid on histamine forming capacity, histaminase activity or histamine release.

PubMed Disclaimer

References

    1. J Physiol. 1957 Jul 11;137(2):169-78 - PubMed
    1. Br J Pharmacol Chemother. 1965 Jun;24:725-34 - PubMed
    1. Biochem Pharmacol. 1974 Feb 1;23(3):637-41 - PubMed
    1. Biochem Pharmacol. 1974 Feb 1;23(3):643-7 - PubMed
    1. J Clin Pathol. 1966 Jul;19(4):402 - PubMed

Publication types

LinkOut - more resources