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. 1970 Jun;24(2):294-9.
doi: 10.1038/bjc.1970.34.

Radiation-induced osteosarcoma in the rat as a model for osteosarcoma in man

L M Cobb
Free PMC article

Radiation-induced osteosarcoma in the rat as a model for osteosarcoma in man

L M Cobb. Br J Cancer. 1970 Jun.
Free PMC article

Abstract

A technique is described for the local induction of osteosarcoma in the rat by implanting (32)P-impregnated polyvinyl chloride discs into the distal femoral metaphysis. The incidence of osteosarcomata after 18 months was 28%. A comparison is made of the pathology of the radiation-induced osteosarcoma in the rat and the "spontaneous" osteosarcoma in man. The possible value of the rat osteosarcoma model is discussed.

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References

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